TY - JOUR ID - 9430 TI - The Effect of Adding Different Antibiotics on the Resistance against Bacterial Leakage of AH 26 Sealer JO - Journal of Dental Materials and Techniques JA - JDMT LA - en SN - 2322-4150 AU - Mohammadi, Zahed AU - Giardino, Luciano AU - Palazzi, Flavio AU - Paragliola, Raffaele AU - Grandini, Simone AU - Jafarzadeh, Hamid AD - Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran; Iranian National Elite Foundation, Tehran, Islamic Republic of Iran. AD - Private Practice, Crotone, Italy AD - Department of Odontostomatological and Maxillofacial Sciences, Federico II University of Naples, Naples, Italy AD - Department of Endodontics and Restorative Dentistry, University of Siena, Siena, Italy AD - Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 6 IS - 4 SP - 170 EP - 175 KW - AH26 sealer KW - Antibiotics KW - Bacterial Leakage KW - Enterococcus faecalis DO - 10.22038/jdmt.2017.9430 N2 - Aim: Most endodontic sealers show antimicrobial activity before setting, but most of them also lose this ability after setting. Addition of an antibiotic may affect the properties of sealers such as sealing ability, setting time, and so on. The aim of this study was to assess whether the addition of antibiotics (amoxicillin, doxycycline, and clindamycin) improves the sealing ability of AH 26 sealer. Materials and Methods: Seventy extracted human mandibular premolars were used. After cleaning and shaping the canals, the teeth were divided into six groups: group 1: gutta-percha and AH 26 sealer, group 2: gutta-percha and AH 26 sealer+doxycycline, group 3: gutta-percha and AH 26 sealer+amoxicillin, group 4: gutta-percha and AH 26 sealer+clindamycin, group 5: gutta-percha without sealer (positive control), and group 6: gutta-percha and AH 26 sealer (the root surfacewere covered with nail varnish) (negative control). A microbial leakage model was used to assess the sealing ability. Results: Group 2 had the greatest resistance against bacterial leakage. Furthermore, combining AH 26 sealer with amoxicillin and clindamycin increased mean leakage time compared to AH 26 sealer solely. However, the differences between groups 1 and 3 as well as between groups 1 and 4 were not statistically significant. Conclusion: Incorporating antibiotics especially doxycycline into AH 26 sealer increases its resistance against bacterial leakage.       UR - https://jdmt.mums.ac.ir/article_9430.html L1 - https://jdmt.mums.ac.ir/article_9430_49be05b616cdf2251e13805a8079c853.pdf ER -