TY - JOUR ID - 7611 TI - Inhibitory Effect of Curcumin on Candida-albicans compared with Nystatin: an in-vitro Study JO - Journal of Dental Materials and Techniques JA - JDMT LA - en SN - 2322-4150 AU - Babaii, Neda AU - Zamaninejad, Shiva AD - Associate Professor of Oral and Maxillofacial Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran AD - Assistant Professor of Pediatric Dentistry, Faculty of Dentistry, Golestan University of Medical Science, Gorgan, Iran Y1 - 2016 PY - 2016 VL - 5 IS - 4 SP - 196 EP - 201 KW - Curcumin KW - antifungal effect KW - Candida albicans KW - dimethyl sulfoxide DO - 10.22038/jdmt.2016.7611 N2 - Introduction: Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. on basis of recent studies; it has antifungal and antibacterial effects. The aim of this study was in-vitro evaluation of antifungal effect of curcumin on candida albicans and comparing it with nystatin. Methods: after preparing curcumin powder, 3 laboratory methods were used to evaluate antifungal effect. The first method was cell count technique, used to evaluate the amount of candida albicans after time, in different concentrations of curcumin in Dimethyl sulfoxide (DMSO). The second was cup bioassay, in which inhibitory a zone of curcumin in DMSO was evaluated in sabouraud culture plates; and in third method, inhibitory zones of dried disks; which contained curcumin in DMSO were evaluated. Results: the result of all three methods showed that curcumin has antifungal effect and this effect increases in more concentrations. Conclusion: curcumin has apparent and dose dependent antifungal effect on candida albicans. UR - https://jdmt.mums.ac.ir/article_7611.html L1 - https://jdmt.mums.ac.ir/article_7611_d597d70055cebc845cb9e37ac111aa46.pdf ER -